What naloxone is
Naloxone is a medicine that rapidly reverses the effects of an opioid overdose. Narcan is the most familiar brand of naloxone nasal spray. The FDA calls naloxone the standard treatment for opioid overdose.
Florida’s iSaveFL program explains that naloxone works by blocking opioid receptors in the brain. It is mostly given as a nasal spray, and it can also be given by injection. Someone who is not having an overdose will not be harmed by a dose.
Naloxone works on opioids, including heroin, fentanyl and prescription painkillers. It doesn’t reverse alcohol, benzodiazepines or xylazine. Still, the CDC says to give it in any suspected overdose, because opioids are so often mixed into other drugs.
You can buy it without a prescription
On March 29, 2023, the FDA approved Narcan 4 mg naloxone nasal spray for over-the-counter use, the first naloxone product approved without a prescription. The FDA said this opens the way for sales in drug stores, convenience stores, grocery stores and gas stations, as well as online.
Other forms and doses of naloxone may still need a prescription. Ask a pharmacist if you aren’t sure which product you have.
If cost is a worry, start with the free options below. If you have health insurance, you can also ask the pharmacist whether your plan helps pay for it.
Free naloxone in Jacksonville
Florida Department of Health in Duval County. DOH-Duval says it is giving out Narcan to members of the community free of charge. Its page lists these Jacksonville locations:
- 515 West 6th St., Jacksonville, FL 32206 (the Pharmacy Center, Comprehensive Care Center, Center for Women and Children and other clinics at this address)
- 3225 University Blvd. South, Jacksonville, FL 32216 (South Jacksonville Family Health Center and nearby services)
- 921 N. Davis St., Bldg. B, Suite 350, Jacksonville, FL 32209 (Environmental Health)
- 5917 105th St., Jacksonville, FL 32244 (Wesconnett WIC and Nutrition Services)
- 120 King St., Jacksonville, FL 32204 (Westside Children’s Dental Center)
Hours and locations can change, so check the DOH-Duval page or call 904-253-1488 before you go. The program’s email is PreventOverdoseDuval@FLHealth.gov.
iSaveFL, statewide. The Florida Department of Children and Families (DCF) runs the Overdose Prevention Program and its iSaveFL campaign, and the Florida Department of Health works with DCF on it. DCF says the program has given out free naloxone since 2016 through a network of enrolled distributors, including treatment providers, shelters, hospital emergency departments, health centers and sober living homes. The iSaveFL site has a tool to find a local provider.
How to respond to an overdose
Check and call
Signs include not waking up, slow or shallow breathing, purplish lips or nails and pinpoint pupils, according to NIDA. Call 911.
Give naloxone
Follow the package directions. The CDC notes more than one dose may be needed, and rescue breaths help, especially if xylazine may be involved.
Stay with them
Naloxone can wear off, and it can bring on withdrawal in someone who depends on opioids. Stay until help arrives.
After the overdose: the next step
An overdose is a turning point for many families. Naloxone buys time, but it isn’t treatment. Medication for opioid use disorder, such as buprenorphine or methadone, is what NIDA calls the standard of care. Read our fentanyl and opioid treatment page and our medication-assisted treatment guide.
Medication-assisted treatment near Jacksonville
Free listings, checked against Florida DCF. Many programs can also give you naloxone. Just ask.
MedMark Treatment Centers Jacksonville
5600 Spring Park Road Suite 101, Jacksonville
Meridian Healthcare (Putnam County Clinic)
3314 Crill Avenue, Palatka
New Season Treatment Center (Duval)
590 Ellis Road South, Jacksonville
New Season Treatment Center (Jacksonville)
4427 Emerson Street Bldg 4, Jacksonville
New Season Treatment Center (Orange Park)
1241 Blanding Boulevard Suite 5, Orange Park
New Season Treatment Center (St. Augustine)
3574 US 1 South Suites 101-104, St. Augustine
North Florida Comprehensive Treatment Center
6639 Southpoint Pkwy Suite 108, Jacksonville
Naloxone: common questions
Do I need a prescription for Narcan?
Not for Narcan 4 mg nasal spray. The FDA approved it for over-the-counter sale in 2023. Some other forms of naloxone still require a prescription.
Can naloxone hurt someone?
iSaveFL says someone who is not having an overdose will not be harmed by naloxone. In a person who depends on opioids, the FDA notes it can cause sudden withdrawal, with symptoms like body aches, vomiting, a racing heart and restlessness.
Does naloxone work on fentanyl?
Yes. The CDC says naloxone can reverse an overdose from opioids, including fentanyl. More than one dose may be needed.
Who should carry naloxone?
Anyone who might witness an opioid overdose: parents, partners, roommates and friends. iSaveFL encourages Floridians to get a free kit, especially if someone they know is at risk.
